Patients are placed on mechanical ventilators because of an overwhelming immune response, which causes runaway inflammation that leads to ARDS and can progress to organ failure and death. The immunomodulation aspect of MSCs, and possibly remestemcel-L, is what might explain the encouraging results from the trial of COVID-19 patients in New York City. So far, says Itescu, Mesoblast’s treatment has been tested in clinical trials in over 1,100 graft-vs-host patients. After all, the flagship Motley Fool Share Advisor newsletter he has run for more than eight years has provided thousands of paying members with stock picks that have doubled, tripled or even more. The first is the interim analysis of Ryoncil’s Phase 3 trials in ventilator dependent COVID-19 patients. He graduated from the State University of New York College of Environmental Science and Forestry (2012) with a Bachelor of Science in Bioprocess Engineering and from Carnegie Mellon University (2016) with a Master of Science in Materials Science & Engineering. Nikhil hopes to help readers become better investors by focusing on stock selection and risk management.© 2009 - 2020 The Motley Fool Australia Pty Ltd. All rights reserved.ACN: 146 988 052 | Australian Financial Services Licence (AFSL): 400691 Personal Finance

Mesoblast Soars 219% on Promising COVID-19 Clinical Trial Data The small-scale study, including just 12 patients, could signal big potential for the stem cell company's drug candidate. Thinly traded Mesoblast Limited (NASDAQ:MESO) rockets 51% premarket on average volume in reaction to its announcement of an 83% (n=10/12) survival rate … The product is currently undergoing Phase 3 trials in the United States on COVID-19 patients with acute respiratory distress syndrome.Ryoncil is already in a number of other clinical trials targeted at reducing inflammatory conditions in patients with steroid-refractory acute graft versus host disease (SR-aGVHD).There are two important catalysts in the near future that could send the Mesoblast share price soaring. (TMFBlacknGold)

Mesoblast remains unproven, but if the results from the first 12 patients treated with remestemcel-L hold up in larger populations, then it could offer a promising treatment for the most significant cause of COVID-19 deaths.
Mesoblast Ltd. ADR Mesoblast Ltd. is a biopharmaceutical company, which engages in the research, development, and market of mesenchymal lineage adult stem cell technology platform. Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services.Although the results are from only 12 people, the outcomes are remarkable. Get the latest Mesoblast Limited (MESO) stock news and headlines to help you in your trading and investing decisions. Mesoblast is developing remestemcel-L to treat a range of health disorders. Nikhil has extensive experience in financial markets with a background in economics and having worked as an Australian equities trader for a proprietary firm. Find the investing style that's right for you. HotCopper has news, discussion, prices and market data on MESOBLAST LIMITED. The consensus price target fell 23% to AU$3.98, with the analysts clearly concerned about the company following the weaker revenue and earnings outlook. The company is scheduled to meet with the US Food and Drug Administration (FDA) on 13 August. Retirement May 7, 2020 Latest News Mesoblast (ASX:MSB) says the first patients have been dosed in its 300-patient randomised placebo-controlled Phase 2/3 trial in the US of its allogeneic cellular medicine remestemcel-L in COVID-19 infected patients with moderate to severe acute respiratory distress syndrome (ARDS) on ventilator support. Given the current state of the world, that track record might do little to deter health systems desperate for solutions. If remestemcel-L helps to combat the body's inflammatory responses, then it could help to significantly reduce fatal outcomes related to COVID-19.Many companies have attempted to develop stem cell therapies for a range of diseases. For more information please see our The Motley Fool Australia, PO Box 4635, Ashmore, Qld 4214Nikhil Gangaram is currently studying dentistry, however, his first love is the stockmarket which he believes to be the greatest wealth generator in the world. His investment philosophy has developed from being a short-term speculator to building long-term and sustainable portfolio returns.


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